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A new study led by Indian-origin researcher Hirsh D. Trivedi emphasizes the pivotal role of exercise in managing metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD). MASLD is a chronic liver condition marked by fat accumulation in the liver, typically affecting individuals with diabetes, obesity, high blood pressure, or high cholesterol.

Conducted at Cedars-Sinai Medical Center in California, the study found that exercise benefits patients across all stages of MASLD, even those with cirrhosis, a severe form of liver scarring. The research, published in the journal Liver International, highlighted that exercise not only aids weight loss but also reduces liver fat, improves inflammatory biomarkers, and enhances cardiovascular health.

“Personalized exercise regimens should be prioritized for all patients, including those receiving pharmacotherapy,” the researchers noted.

Dr. Jonathan G. Stine, part of the research team, shared on social media platform X, “Exercise is a great therapeutic tool across all stages of liver disease, including advanced liver disease! Would not limit physical activity solely based on liver disease stage, and even folks living with cirrhosis can safely and effectively exercise.”

The findings, derived from a review of multiple preclinical and clinical studies, revealed a consistent association between increased physical activity and improved liver disease outcomes. The researchers urged healthcare providers to adopt evidence-based, systematic approaches when prescribing exercise for MASLD patients.

“Regular physical activity improves insulin sensitivity, reduces hepatic fat accumulation, and lowers biomarkers of liver inflammation,” the team concluded, emphasizing that exercise should remain a cornerstone intervention for MASLD management. They also called for further research to develop optimized exercise protocols tailored to individual patient needs.

This study reinforces the critical role of lifestyle changes in tackling chronic liver disease and provides hope for better patient outcomes through targeted exercise interventions.

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