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During week 1 to 7 November 2021, a slight upward trend (1% increase) in new weekly cases was observed, with over 3.1 million new cases reported. Over 48 000 new deaths were reported, a 4% decrease from the previous week. The WHO European Region reported increases in the case and death incidence, while other regions reported declines or stable trends. As of 7 November, over 249 million confirmed cases and over 5 million deaths have been reported.