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Researchers at the University of Auckland have commenced a clinical trial to explore castor oil as a potentially safe and natural treatment for dry eye conditions. Following a successful pilot study, the team is investigating the effectiveness of cold-pressed castor oil, enhanced with manuka and kanuka oils, in alleviating symptoms associated with dry eye diseases. Dry eye illness affects around 58% of the population aged 50 and above in Australia, making it a prevalent concern.
Dry eye disease is influenced by various risk factors, including advanced age, menopause, increased screen time, and contact lens wear. The leading cause of dry eye illness is blepharitis, a chronic disease without a known cure, contributing to over 80% of cases. Current treatments often involve antibacterials and anti-inflammatories, but their long-term use is hindered by significant side effects and the risk of antimicrobial resistance.
Doctoral candidate and lead clinical investigator, Catherine Jennings, highlights the challenges faced by patients dealing with dry eye symptoms, impacting their quality of life and work productivity. The ongoing clinical trial utilizes a product containing cold-pressed castor oil, combined with manuka and kanuka oils, applied using a rollerball attached to a small glass bottle.
The research team’s pilot study involved 26 patients with blepharitis, treated with castor oil over four weeks. Positive outcomes included reduced redness of the lid margin, decreased thickening of the eyelid, a decline in bacterial profusion, and reduced eyelash crusting. Building on this success, the team has initiated a more extensive double-blinded, randomized, and placebo-controlled study, aiming to recruit 92 participants to provide robust scientific evidence for clinicians.
Principal investigator Professor Jennifer Craig emphasizes the goal of improving the quality of life for a large group of patients using a natural, safe, and effective product. Castor oil, derived from the Riccinus communis shrub, has been historically used for therapeutic purposes, including eye cosmetics and makeup removers. The hope is that the study will offer evidence-based guidance for clinicians, considering castor oil as a potential management option for patients suffering from blepharitis, ultimately enhancing their overall quality of life.
