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A groundbreaking study conducted by researchers at the University of Cambridge sheds light on the heightened risk of second cancers among survivors of breast cancer, particularly in individuals from socioeconomically deprived backgrounds.
Breast cancer remains the most prevalent form of cancer in the UK, with over 99% of cases diagnosed in women. While advancements in early detection and treatment have led to improved survival rates, concerns about the potential development of second primary cancers have persisted.
To address these concerns, researchers analyzed data from nearly 600,000 breast cancer survivors in England, spanning over two decades. Published in Lancet Regional Health – Europe, their findings underscore the substantial risk of second cancers among survivors, with notable variations based on factors such as age at diagnosis and socioeconomic status.
Lead author Isaac Allen emphasized the significance of understanding the link between breast cancer and subsequent cancers, stating, “Knowing this can help inform conversations with their care teams to look out for signs of potential new cancers.”
The study revealed that female survivors of breast cancer faced double the risk of developing contralateral breast cancer compared to the general population. Additionally, they were at significantly elevated risks of endometrial, ovarian, and myeloid leukemia cancers. Age at diagnosis played a crucial role, with younger survivors demonstrating a higher risk of developing second primary cancers.
Furthermore, individuals from socioeconomically deprived backgrounds faced a 35% greater risk of second primary cancers, primarily driven by non-breast cancer risks such as lung, kidney, and stomach cancers. This disparity underscores the urgent need to address health inequalities and implement targeted interventions to mitigate cancer risks in vulnerable populations
