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A new study published in JAMA Network Open has shed light on the concerning effects of salt-based nicotine and menthol flavoring in e-cigarettes, particularly among young adults. The research indicates that these formulations, especially at higher concentrations, significantly increase nicotine uptake and may heighten the risk of nicotine dependence.
The study, involving 72 participants aged 21-25, explored how different nicotine formulations and flavorings influence nicotine levels and user experience. Participants were given various e-cigarettes containing either salt-based or freebase nicotine at 1% or 5% concentrations, with some also containing menthol flavoring. Blood samples were collected at baseline, five, 10, and 35 minutes into each vaping session. Researchers also used the Questionnaire of Smoking Urges (QSU) to assess nicotine cravings and withdrawal symptoms.
Key findings revealed that salt-based nicotine e-cigarettes, particularly those with a 5% nicotine concentration, led to the highest nicotine uptake. Plasma nicotine levels averaged 11.2 ng/mL at five minutes and 17.2 ng/mL at 35 minutes, demonstrating a rapid increase in nicotine absorption. Specifically, there was a 94% increase in plasma nicotine levels within the first five minutes of vaping. Furthermore, menthol flavoring was found to increase plasma nicotine levels by 18% at the 35-minute mark.
Participants also reported significantly more positive feelings when using salt-based nicotine e-cigarettes compared to freebase ones, with average scores of 42.8 and 32, respectively. The 5% freebase nicotine with tobacco flavor resulted in the least positive subjective outcomes, while the 5% menthol-flavored nicotine salts received the highest positive scores.
These results suggest that the prevalent use of salt-based nicotine formulations, especially at higher concentrations, may significantly contribute to nicotine dependence among young adults who vape. The study’s authors emphasize the need for stricter regulation of these products to mitigate potential health risks.
“The rapid and high nicotine delivery from salt-based e-cigarettes, combined with the appealing effects of menthol, presents a serious concern for nicotine addiction among young adults,” stated a researcher involved in the study.
This study underscores the importance of understanding the specific effects of different e-cigarette formulations and flavorings on nicotine uptake and dependence, particularly in vulnerable populations like young adults.
Disclaimer: This news article is based on the provided study information and is for informational purposes only. It is not intended to provide medical advice. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment. The results of this study may not be generalizable to all populations, and further research is needed to fully understand the long-term effects of salt-based nicotine and menthol flavoring in e-cigarettes.(https://www.emedinexus.com/post/47410/Study-Highlights-Effects-of-Salt-Nicotine-and-Menthol-in-Youth-Vaping-Trends)
