0
0
A recent study published in JAMA Dermatology has shed light on how product formulation and production processes influence benzene levels in benzoyl peroxide-containing acne treatments. Benzoyl peroxide is a cornerstone treatment for acne, but concerns have been raised over the potential formation of benzene, a known carcinogen, in some formulations.
Investigators reanalyzed data from 111 acne products to assess how product type, age, and ingredient composition might affect benzene formation. Their findings suggest that production methods and ingredient selection play a crucial role in determining benzene levels. Notably, products with elevated benzene levels were more likely to have been exposed to higher temperatures during production, while those with lower benzene levels contained greater amounts of antioxidants (such as butylated hydroxytoluene) and acidic ingredients (like benzoic acid).
The study’s authors emphasize that these findings offer opportunities to refine formulation, production, and distribution practices to minimize benzene formation. They also refute concerns that benzoyl peroxide products degrade into clinically significant levels of benzene at room temperature. Instead, much of the variation in benzene levels can be attributed to specific formulation characteristics.
This research underscores the importance of careful ingredient selection and optimized manufacturing processes to ensure the safety and efficacy of benzoyl peroxide treatments. Moving forward, further studies will assess whether modifying these factors can effectively reduce benzene presence in acne treatments.
More information: The role of formulation on benzene formation in benzoyl peroxide products, JAMA Dermatology (2025). DOI: 10.1001/jamadermatol.2024.6443
Journal Information: JAMA Dermatology
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Patients should consult a healthcare professional before making any changes to their skincare regimen.
