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A recent pilot study has strengthened the connection between Long Covid and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), providing valuable insights into shared immune pathways. Long Covid, a condition affecting approximately 10% of individuals post-SARS-CoV-2 infection, exhibits similarities to ME/CFS, a post-stressor fatigue condition. While both conditions share post-viral fatigue symptoms, the study, published in Scientific Reports, delved into the molecular analysis of immune cell proteins.
The research revealed overlapping protein clusters and enriched molecular pathways, particularly in immune functions, suggesting a common immune pathophysiology in both conditions. Additionally, disruptions in mitochondrial functions involved in energy production were observed in both Long Covid and ME/CFS. Notably, the immune system activity of Long Covid patients one year after infection displayed marked differences compared to a healthy control group, resembling the immune profile of ME/CFS patients who had experienced the condition for an average of 16 years.
Lead author Professor Warren Tate emphasized that Long Covid, stemming from SARS-CoV-2, is a specific instance of ME/CFS. The study suggests that individuals affected by endemic viruses or historical viral outbreaks may also experience ME/CFS-like symptoms. The findings underscore the need for comprehensive support for those debilitated by disrupted immune systems, impaired energy production, and altered brain regulation. The study’s results pave the way for a coordinated treatment strategy, with the potential application of immunotherapy tailored to address the specific immune system changes documented in ME/CFS and Long Covid patients. The research signals a revolutionary phase in immunotherapy development, offering hope for improved treatment approaches for these conditions.
