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In a groundbreaking study by Di Sang et al., the devastating effects of prolonged sleep deprivation in mice have been uncovered, shedding light on a critical link between the brain and the immune system. The research introduces a unique “curling prevention by water” method, resulting in a remarkable 96% wakefulness in mice. After just four days of this sleep deprivation, mice experienced severe inflammation, leading to an alarming 80% mortality rate.
The study highlights a surge in prostaglandin D2 (PGD2) levels within the brain due to sleep deprivation, prompting increased PGD2 efflux across the blood-brain barrier. This heightened efflux, mediated by the ATP-binding cassette subfamily C4 transporter, led to the accumulation of circulating neutrophils and triggered a cytokine-storm-like syndrome. The disruption of the PGD2/DP1 axis significantly mitigated the inflammation induced by sleep deprivation, revealing the central role of PGD2 in driving pathological consequences within the peripheral immune system.
This research, published by Elsevier Inc., signifies a crucial breakthrough in understanding the profound impacts of sleep-related changes in PGD2, emphasizing the intricate connection between sleep patterns and immune responses. The findings could potentially pave the way for new strategies to manage sleep-related inflammatory disorders.
