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SINGAPORE – Recent scientific findings indicate that microbes, similar to those found in probiotic drinks, could play a significant role in improving mental health. A study conducted by researchers from Duke-NUS Medical School and the National Neuroscience Institute, Singapore, has uncovered a vital link between gut microbes and anxiety-related behaviors.
The research, published in EMBO Reports, highlights the influence of indoles, organic compounds produced by certain gut bacteria, on brain activity associated with anxiety. By examining mice in germ-free environments, where no live microbes are present, the scientists observed heightened anxiety-related behaviors compared to those exposed to resident live microbes.
This increased anxiety was linked to heightened activity in the basolateral amygdala, a brain region crucial for processing emotions like fear and anxiety. Further investigation revealed that this activity was associated with calcium-dependent SK2 channels, specialized proteins within brain cells tied to anxiety behavior. The presence of live microbe metabolites, such as indoles, appeared to regulate these SK2 channels, preventing neurons from becoming overly excited.
“Our research suggests that indoles, produced by certain gut microbes, act like a clutch, preventing neurons from firing too frequently and thus mitigating anxiety,” explained a lead researcher.
The implications of this study are far-reaching, particularly in light of the rising prevalence of mental health disorders. In Singapore, one in seven people experiences a mental health disorder, while in India, the National Mental Health Survey (NMHS) 2015-16 found that 10.6 percent of adults suffer from mental disorders.
The researchers believe that targeting the gut-brain axis through dietary supplementation with indoles or introducing indole-producing gut microbes as probiotics could offer new avenues for treating anxiety-related disorders. They plan to conduct clinical trials to determine the efficacy of indole-based probiotics or supplements as a natural anxiety treatment in humans.
“If successful, this could pave the way for a holistic approach to managing both gut and mental health,” said a spokesperson from the research team.
It is important to note that while probiotic drinks may offer potential benefits, only those certified by relevant health and food authorities should be considered for such purposes.
Disclaimer:
- This news article is based on recent research findings and should not be interpreted as medical advice.
- The benefits of probiotic drinks for mental health are still being investigated, and further clinical trials are necessary to confirm these findings.
- Consult with a healthcare professional before making any changes to your diet or treatment plan, especially if you have existing mental health conditions.
- Only probiotic drinks that are certified by relevant health/food authorities offer potential health benefits.
- This article is based on research primarily conducted on mice, and further research is necessary to confirm the same results in humans.
(https://www.theweek.in/news/health/2025/03/19/how-microbes-in-probiotic-drinks-can-improve-your-mental-health-research-reveals-benefits.html)
