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Recent studies led by researchers at the Broad Institute of MIT and Harvard, in collaboration with Mass General Brigham, have significantly expanded our understanding of the genetic factors contributing to atrial fibrillation (AF), a prevalent heart condition characterized by an irregular heartbeat that can lead to stroke and heart failure.
In one study, published in Nature Genetics, the team analyzed data from numerous large-scale genetic studies, identifying over 350 common DNA variants associated with an increased risk of AF. This discovery effectively doubles the number of known common genetic risk factors for the condition.
The second study, also featured in Nature Genetics, examined genetic sequencing data from thousands of individuals with AF. This analysis pinpointed rare genetic changes in several genes, highlighting the genetic connections between AF and structural heart abnormalities known as cardiomyopathies.
These findings not only enhance our understanding of the genetic architecture of AF but also suggest potential new targets for therapeutic development. As AF affects more than 5 million Americans, these insights offer hope for improved treatments in the future.
Disclaimer: This article is based on research findings and should not be considered medical advice. For personalized information, please consult a healthcare professional.
