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Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake mushrooms as well as fermented foods. This article describes how this compound may improve health and lifespan.
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Improved healthspan in animals
- Treatment with ergothioneine from young adulthood extended the lifespan of worms.
- Worms treated with ergothioneine showed increased mobility, stress resistance and reduced age-related biomarkers.
- Rats treated with ergothioneine showed improved endurance, muscle mass, vascularization of muscle tissue and the number of muscle stem cells.
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Ergothioneine’s mechanism of action
- Ergothioneine acts as an alternative substrate for the enzyme cystathionine-γ-lyase (CSE).
- CSE plays a central role in the production of hydrogen sulfide (H₂S), which protects cells from oxidative stress.
- Ergothioneine stimulates persulfidation, which in turn boosts the formation of NAD+—a known coenzyme that has a positive effect on the lifespan.
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Future studies
- A study with healthy human subjects is planned to investigate the performance-enhancing effects of ergothioneine.
Ergothioneine is a promising compound that may lead to improved health and lifespan. More research is needed to confirm its effects in humans.
Note: This is a summary of the article. You can find the full article here: Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation.
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