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A recent abstract presented at the annual meeting of the Radiological Society of North America raises concerns about the potential side effects of levothyroxine, a commonly used drug to treat hypothyroidism. According to a study from Johns Hopkins University School of Medicine, levothyroxine may lead to a gradual reduction in bone mass and density in older adults, even in those with normal thyroid hormone levels.
The study, which followed individuals over a 6-year period, found that older adults aged 65 and above who took levothyroxine showed a decrease in total body bone mass and density. The findings suggest that long-term use of levothyroxine in older adults could contribute to unwanted side effects, including a negative impact on leg mass.
Data from the Baltimore Longitudinal Study of Aging were analyzed, including 32 males and 49 females, all aged 65 or older. The participants were matched with a quasi-control group based on factors such as biological sex, BMI, age, race, alcohol and smoking history, other treatments, and thyroid-stimulating hormone (TSH) levels. Bone mass and density were measured using Dual-Energy X-ray Absorptiometry during two separate visits.
The results of the study highlighted a concerning trend: individuals with normal thyroid hormone levels who were taking levothyroxine had lower bone mass and density. This suggests that levothyroxine use could potentially contribute to bone loss, even when the drug is taken at the correct dosage. Experts are raising concerns about the possible link to osteoporosis, a condition marked by weakened bones and an increased risk of fractures.
As levothyroxine is widely prescribed for hypothyroidism, this study highlights the importance of closely monitoring the bone health of older adults using the medication.
Disclaimer: The findings of this study are based on the analysis of data from the Baltimore Longitudinal Study of Aging and may not apply to all individuals. Before making any changes to your treatment plan, please consult with your healthcare provider.
(Source: Medical News Today)
