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Adelaide, Australia – A groundbreaking study conducted by researchers at the University of Adelaide’s Australian Dysautonomia and Arrhythmia Research Collaborative (ADARC) has revealed a significant link between poor brain blood flow and Postural Orthostatic Tachycardia Syndrome (POTS), a debilitating condition affecting the autonomic nervous system.
The study, published in Scientific Reports, utilized nuclear medicine brain scans (SPECT) to examine blood flow in 56 POTS patients experiencing severe “brain fog.” This is believed to be the first study to identify reduced brain blood flow in POTS patients even when lying down, providing crucial insights into the condition.
POTS, which disproportionately affects younger women, disrupts the autonomic nervous system, responsible for regulating unconscious bodily functions like breathing and blood circulation. Symptoms worsen upon standing, leading to dizziness, cognitive impairment, rapid heart rate, and fatigue.
“We found 61% of participants had reduced blood flow in key brain areas, even when lying down. This is the first clear evidence of poor brain circulation in POTS even while patients are lying down using an imaging technique which is widely accessible to doctors,” stated Dr. Seeley, lead researcher.
The SPECT scans, conducted in collaboration with the South Australian Health and Medical Research Institute (SAHMRI), revealed that areas of the brain responsible for executive function, sensation, and movement were most affected. This explains the common “brain fog” experienced by POTS patients, including difficulties with planning, decision-making, concentration, and sensory processing.
The study also highlights the often-delayed diagnosis of POTS, which can take an average of seven years in Australia due to under-recognition and limited access to diagnostic testing.
Furthermore, ADARC researchers have previously established a connection between Long COVID and POTS, with 79% of Long COVID patients in their study meeting the criteria for POTS. POTS can also develop following viral infections, concussions, surgery, or pregnancy.
“Considering the young age of our POTS cohort, predominantly comprising females, and the concerning implications of blood flow on cognitive function and sensory function, our findings raise questions about the potential impact on educational progression, workforce engagement, and overall social and economic well-being,” Dr. Seeley emphasized.
The researchers call for further investigation into the mechanisms underlying brain blood flow issues in post-viral and autonomic syndromes, as well as the exploration of potential therapies and interventions.
“We have seen POTS impact people from all walks of life, leaving people who were once able to function well in society now with a much-reduced quality of life. These results highlight the need for further research to understand the pathways underlying brain blood flow issues in post-viral and autonomic syndromes. Future prospective studies may explore the role of therapies and interventions in the management of brain blood flow,” Dr. Seeley said.
More information can be found in the published study: Marie-Claire Seeley et al, Novel brain SPECT imaging unravels abnormal cerebral perfusion in patients with postural orthostatic tachycardia syndrome and cognitive dysfunction, Scientific Reports (2025). DOI: 10.1038/s41598-025-87748-4
Disclaimer: This news article is based on the provided information and should not be taken as medical advice. Individuals experiencing symptoms of POTS or related conditions should consult with a healthcare professional for diagnosis and treatment. Research in this area is ongoing, and further studies may yield additional insights.
