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Munich, Germany – While intermittent fasting has gained widespread popularity for weight loss and other health benefits, a recent animal study suggests that it may be unsafe for teenagers, potentially impairing their cellular development.
A team of German researchers from the Technical University of Munich (TUM), LMU Hospital Munich, and Helmholtz Munich has revealed that age significantly influences the effects of intermittent fasting. Their findings, published in the journal Cell Reports, indicate that chronic intermittent fasting disrupted the development of insulin-producing beta cells in young mice.
Intermittent fasting is a dietary regimen that restricts eating to a six- to eight-hour window each day. It is widely recognized for its potential benefits in managing diabetes, improving heart health, and aiding weight loss. However, the latest study highlights possible risks for children and adolescents.
Adverse Effects on Beta Cells in Young Mice
“Our study confirms that intermittent fasting is beneficial for adults, but it might come with risks for children and teenagers,” said Stephan Herzig, a professor at TUM and director of the Institute for Diabetes and Cancer at Helmholtz Munich.
The study involved adolescent, adult, and older mice subjected to intermittent fasting, where they remained without food for one day and were fed normally for two days over a span of ten weeks. The results showed that while insulin sensitivity improved in both adult and older mice—enhancing their ability to regulate blood sugar levels—the adolescent mice exhibited a troubling decline in beta cell function.
Beta cells in the pancreas are responsible for insulin production, a crucial hormone for regulating blood sugar levels. A deficiency in insulin production is linked to diabetes and metabolic disorders. “Intermittent fasting is usually thought to benefit beta cells, so we were surprised to find that young mice produced less insulin after the extended fasting,” said Leonardo Matta from Helmholtz Munich.
Link to Human Diabetes Cases
Further analysis of pancreatic tissue revealed that the beta cells in younger mice failed to mature properly. Comparisons with human tissue data showed similarities between these findings and cases of Type 1 diabetes, where an autoimmune response destroys beta cells.
The findings suggest that while intermittent fasting may be a useful dietary intervention for adults, its safety for younger individuals remains uncertain. Researchers recommend further studies to determine the long-term effects of intermittent fasting on adolescent metabolism and cellular development.
Disclaimer: This article is based on an animal study and further research is needed to confirm the effects on human adolescents. Individuals considering intermittent fasting, particularly teenagers, should consult a healthcare professional before making dietary changes.
