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A recent study highlights a significant association between nonmalignant gynecological diseases and heart-related conditions.
Lugano, Switzerland – A new systematic review and meta-analysis published in Heart has revealed that nonmalignant gynecological diseases (NMGD) are linked to an increased risk of cardiovascular and cerebrovascular disease (C/CVD). The study, led by Giorgia Elisabeth Colombo, M.B., Ch.B., from the Ospedale Regionale di Lugano, underscores the need for heightened awareness among physicians regarding this association.
The research involved a comprehensive literature review analyzing data from 28 studies, comprising a total of 3,271,242 participants. The composite C/CVD outcome included ischemic heart disease, cerebrovascular disease, heart failure, and peripheral vascular disease.
Key Findings:
- Individuals with NMGD exhibited a significantly higher risk of developing C/CVD (summary relative risk [SRR], 1.28; I2 = 65.3%).
- The risk was notably elevated for ischemic heart disease (SRR, 1.41; I2 = 73.7%) and cerebrovascular disease (SRR, 1.33; I2 = 91.5%).
- Subgroup analysis revealed that individuals with endometriosis or polycystic ovary syndrome had a particularly heightened risk of C/CVD.
Given these findings, the study authors emphasize the importance of integrating cardiovascular risk assessment into the management of patients with NMGD. “Physicians should be aware of the potential association between NMGD and C/CVD and use this to inform clinical practice in order to mitigate the risk of C/CVD,” the researchers noted.
The authors also called for further prospective longitudinal studies to evaluate these risks comprehensively and develop effective primary prevention strategies for affected individuals.
Industry Disclosures and Further Research
Several authors disclosed affiliations with the pharmaceutical industry, though the study maintains its focus on independent scientific analysis. Future research may build on these findings to explore potential interventions that could help lower cardiovascular risks in individuals with gynecological conditions.
Disclaimer:
This article is for informational purposes only and should not be considered medical advice. Readers are encouraged to consult healthcare professionals for personalized medical guidance. The study findings should be interpreted in the context of potential study biases and require further validation through ongoing research.
