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Researchers uncover genetic links that could pave the way for new treatments and prevention strategies for multimorbidity.
In a groundbreaking study, scientists have identified genetic overlaps in 72 long-term health conditions associated with aging. The largest study of its kind, this research analyzed millions of genetic and patient records to uncover new opportunities for preventing and treating multiple overlapping conditions.
Currently, around nine million people in the U.K. live with two or more long-term conditions simultaneously—a phenomenon known as multimorbidity. The treatment of these conditions accounts for nearly half of the National Health Service (NHS) budget, making it a pressing concern for healthcare providers and policymakers alike.
Led by the University of Exeter Medical School, the GEMINI study examined genetic and clinical data from more than three million individuals across the U.K. and Spain. The findings, published in eBioMedicine, highlight genetic connections between multiple health conditions and offer insights into why some conditions frequently co-occur.
Dr. Joao Delgado, the lead researcher from the University of Exeter Medical School, emphasized the significance of this study, stating, “Overlapping long-term conditions have a huge impact on the lives of millions of people and are difficult and costly to treat. For the first time, we’ve combined analysis of both genetics and clinical records on a massive scale, in a new and robust approach to identify where genes play a critical role in more than one condition.”
The study analyzed over 2,500 combinations of conditions, aiming to identify cases where existing drugs or prevention strategies could be repurposed to delay or prevent multimorbidity. One notable discovery was the role of treatable conditions, such as vitamin B12 deficiency and iron deficiency anemia, in the development of multimorbidity. This breakthrough paves the way for a more personalized approach to healthcare.
Co-author Professor Jane Masoli, also from the University of Exeter Medical School, highlighted the need for a shift in medical research and treatment strategies. “A known problem in treating overlapping health conditions is that clinical services and guidelines largely address single disease groups and not the bigger picture. Studying multiple conditions is really complex and until now, research has mainly focused on one condition at a time.”
She added, “This research provides a platform for understanding what causes overlapping health conditions and will have major benefits in progressing medical knowledge. Treating people holistically rather than addressing each disease separately is likely to improve patient outcomes and reduce healthcare burdens.”
The research aligns with the Government’s Chief Scientific Advisor, Professor Chris Whitty’s, call for improving treatment for people with multimorbidity as a key priority. The findings from the GEMINI study mark a significant step toward developing more effective prevention and treatment strategies for individuals living with multiple chronic conditions.
Disclaimer: This article is based on research findings and is intended for informational purposes only. The study’s results should not be interpreted as direct medical advice. Individuals should consult their healthcare providers for personalized medical guidance and treatment options.
