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Recent findings from a large observational study presented at the SLEEP 2025 annual meeting reveal that excessive daytime sleepiness (EDS) is associated with a significantly higher risk of all-cause mortality in women aged 50 to 65. The research, led by Dr. Arash Maghsoudi of Baylor College of Medicine, analyzed medical records of over 40,000 female veterans with a mean age of 48 years, spanning from 1999 to 2022.
The study found that women in this critical midlife window who scored high on the Epworth Sleepiness Scale—a tool used to assess daytime sleepiness—were 16% more likely to die from any cause compared to their peers with normal sleepiness levels. This association was not observed in younger women or those over 65, suggesting a unique vulnerability during the transition through middle age.
Dr. Maghsoudi emphasized the importance of identifying and managing excessive daytime sleepiness in women approaching their 50s and early 60s. “Identifying middle age as a critical period suggests clinicians should prioritize an Epworth Sleepiness Scale assessment and excessive daytime sleepiness management in women approaching their 50s and early 60s,” he stated in a news release.
The findings also highlight a longstanding data gap, as previous research on EDS and mortality had primarily focused on men. The current results imply that hormonal or metabolic changes during midlife may play a role in the increased risk, though further research is needed to confirm these mechanisms.
Disclaimer:
This article is based on observational research and does not establish causation. The findings are intended for informational purposes and should not be considered medical advice. Always consult a healthcare professional for personalized guidance regarding sleep health and related risks.
