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Cancer remains one of the leading global health challenges, with alarming statistics highlighting the urgent need for prevention and early detection. According to the World Health Organization (WHO), every minute, 38 people are diagnosed with cancer, and 18 people lose their lives to the disease. By 2050, cancer cases are projected to increase by 77%, reaching an estimated 35 million. However, advancements in genetic testing and early screening provide hope in mitigating this growing burden.
The Power of Early Detection
Cancers such as colorectal, breast, and cervical cancer are highly treatable when detected early. Despite this, millions of people avoid screening due to fear, inconvenience, or cost. For instance, colorectal cancer (CRC) has a five-year survival rate of over 90% when diagnosed in its early stages. However, if detected late, survival rates plummet to just 14%.
Colonoscopies, the gold standard for CRC screening, involve uncomfortable preparations, deterring many from undergoing the procedure. Many individuals remain unaware of their risk until symptoms arise, making treatment more challenging. To address this, new DNA-based stool testing methods offer a non-invasive alternative that could significantly increase screening rates and early detection.
Making Screening More Accessible
Traditional screening methods are often invasive, expensive, or inconvenient, contributing to low participation rates worldwide. DNA-based stool testing, a recent innovation, provides a simple, non-invasive alternative that enhances accessibility and encourages more individuals to get screened.
Uncle Jiang, a participant in a public health program in Hangzhou, China, exemplifies the benefits of accessible screening. He had never undergone CRC screening until a routine DNA-based stool test flagged abnormal biomarkers. Initially fearing a late-stage diagnosis, he underwent a follow-up colonoscopy that identified a precancerous condition. The removal of six polyps prevented potential cancer development, demonstrating how early detection saves lives.
Non-Invasive Testing Boosts Compliance
Healthcare professionals and researchers are advocating for DNA-based stool testing as an effective and user-friendly screening tool. Professor Varut Lohsiriwat from Siriraj Hospital, Mahidol University, emphasizes the importance of patient adherence to screening methods. “The best screening method is the one that the patient accepts and adheres to because that’s the method that will actually benefit them,” he stated.
Innovative tests like BGI Genomics’ COLOTECT multi-target stool DNA test offer an at-home alternative to colonoscopy. A study led by Professor Lohsiriwat in Thailand found this testing method to be highly effective, significantly improving screening rates among the Thai population. A 2017 study published in the World Journal of Gastroenterology reported an 88% compliance rate for multitarget stool DNA (mt-sDNA) colorectal cancer screening, with 96% of positive cases proceeding to diagnostic colonoscopies.
Prevention Through Lifestyle Changes
While genetic screening plays a crucial role in early detection, lifestyle modifications remain essential in reducing cancer risk. Research published in CA: A Cancer Journal for Clinicians estimates that up to 40% of cancer diagnoses and nearly half of cancer-related deaths could be prevented through lifestyle changes.
High-intensity exercise has been shown to suppress tumor growth by influencing cancer-related genes. A 2022 study in Frontiers in Molecular Biosciences identified specific genes affected by exercise that play a role in colorectal cancer suppression. The study, conducted on mice undergoing high-intensity aerobic exercise, highlights the need for personalized exercise interventions in cancer prevention.
Furthermore, the World Cancer Research Fund (WCRF) underscores the importance of diet in reducing cancer risk. A balanced diet rich in vegetables, whole grains, and lean proteins can significantly lower the likelihood of developing cancer, while smoking remains a leading cause, responsible for one in five cancer deaths worldwide.
Small Steps, Big Impact
Cancer prevention does not require drastic lifestyle changes. Simple, consistent habits—such as incorporating regular exercise, making healthier food choices, and avoiding tobacco—can have a profound impact over time.
As the world observes World Cancer Day on February 4, under the theme “United by Unique” for 2025–2027, the focus remains on personalized medicine, early detection, and accessible screening. Cancer may be a formidable adversary, but with innovative screening tools and proactive prevention, we can reshape its future and save countless lives.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Readers are encouraged to consult healthcare professionals for personalized medical guidance.
