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Graying hair is a common sign of aging, often considered unavoidable. However, groundbreaking research from Nagoya University in Japan, led by Masashi Kato and Takumi Kagawa, suggests that a natural antioxidant may help slow this process. The study identifies luteolin, a naturally occurring compound found in vegetables such as celery, broccoli, carrots, onions, and peppers, as a potential agent for preventing hair graying. These findings could pave the way for new hair care solutions aimed at maintaining natural hair color.
The Study’s Findings
The research focused on three antioxidants—luteolin, hesperetin, and diosmetin—to assess their anti-graying effects in mice genetically predisposed to graying, similar to humans. The results were striking: mice that received luteolin retained their black fur, while their cage mates without the treatment turned gray. This effect was observed regardless of whether luteolin was administered externally or internally.
“This result was surprising,” Professor Kato said. “While we expected that antioxidants may have anti-graying effects, only luteolin, not hesperetin or diosmetin, demonstrated significant results. This suggests that luteolin may have a unique medicinal effect in preventing graying.”
How Luteolin Works: The Role of Endothelins
Luteolin’s anti-graying effects are linked to its influence on endothelins—proteins that play a crucial role in cellular communication. The study found that luteolin treatments preserved the expression of endothelins and their receptors, supporting healthy signaling pathways and preventing the decline in melanocyte activity, which typically leads to graying.
“Interestingly, luteolin had limited effects on hair cycles, indicating that its primary impact is on pigmentation rather than hair growth or shedding,” Professor Kato explained. “This targeted action makes luteolin a particularly intriguing candidate for addressing age-related hair graying.”
Future Implications
Since the graying process in model mice closely resembles that in humans, researchers are optimistic about translating these findings into human applications. Luteolin is already available as a supplement for both topical and oral use, making it a viable candidate for further development as an anti-graying treatment.
Building on these promising results, Dr. Kagawa envisions broader applications for luteolin in age-related research. “It would be interesting to investigate whether luteolin’s anti-aging effects could also apply to other age-related changes, including balding.”
Disclaimer:
While these findings are promising, further research and clinical trials are needed to determine the effectiveness and safety of luteolin-based treatments in humans. Individuals interested in using luteolin should consult healthcare professionals before incorporating it into their routine.
