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 March 1, 2025 – A recent study conducted by Rutgers Health has revealed a potential association between the use of antibiotics and antifungals and the risk of developing Parkinson’s disease. The research, published in Parkinsonism & Related Disorders, indicates a complex relationship between gut microbiota and brain health.

The study, which analyzed medical records of over 93,000 individuals in the United Kingdom, found that those who received five or more courses of penicillin antibiotics within five years before their diagnosis had approximately a 15% lower risk of Parkinson’s disease compared to those who did not take antibiotics.

This finding supports the growing body of research highlighting the potential influence of gut microbes on Parkinson’s disease, a progressive neurological disorder affecting movement and balance. Some researchers hypothesize that inflammation or toxins produced by certain gut bacteria may contribute to the disease’s development.

Conversely, the study also found that individuals who took two or more courses of antifungal medications within five years before their diagnosis had about a 16% higher risk of Parkinson’s disease.

However, researchers emphasize that these associations are relatively small and should not significantly impact current medical decision-making. The study also acknowledges limitations, such as the inability to account for other factors that could influence gut bacteria, such as diet.

Parkinson’s disease affects over 10 million people worldwide, with prevalence expected to rise as populations age. Researchers believe the disease arises from a complex interplay of genetic and environmental factors.

Future research will focus on identifying specific fungi or bacteria within the gut that may be linked to Parkinson’s disease risk.

Disclaimer: This news article is based on information available at the time of publication and reflects the findings of an observational study. Observational studies can identify associations but cannot establish cause-and-effect relationships. The results of this study should not be interpreted as a recommendation to alter antibiotic or antifungal use without consulting a healthcare professional. Further research is necessary to confirm these findings and understand the underlying mechanisms. This article is for informational purposes only and does not constitute medical advice. Individuals with concerns about Parkinson’s disease or medication use should consult with a qualified healthcare provider.

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