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NOTTINGHAM, UK – A new survey conducted by researchers at the University of Nottingham has found a significant preference among individuals for non-invasive neuromodulation interventions over traditional pharmaceutical drugs for the treatment of neurological and mental health disorders.
The study, published in Scientific Reports, examined public perception of neuromodulation, a technique that alters brain activity through targeted stimuli such as electrical or chemical agents. Researchers are currently developing neuromodulation therapies for conditions like depression, anxiety, schizophrenia, Parkinson’s, and Alzheimer’s disease.
In an online survey involving nearly 800 participants, non-invasive neuromodulation techniques, particularly focused ultrasound stimulation, were rated highly, often surpassing traditional drug-based treatments. Participants were provided with information on five different brain function alteration technologies: pharmaceutical drugs, brain implants, and non-invasive ultrasound, magnetic, and electrical stimulation.
“Providing accurate information to patients significantly improved positive perception of neuromodulation,” said Dr. Marcus Kaiser, lead researcher from the University of Nottingham School of Medicine. “This emphasizes the importance of education and awareness in understanding new medical interventions to foster informed decision making, positive perception of new neuromodulation techniques, and increase adherence to treatment.”
The survey revealed that ultrasound stimulation was considered the safest and most effective option, while pharmaceutical drugs were viewed with skepticism due to concerns about safety, effectiveness, and side effects. Before receiving information, 81% of participants expressed interest in neuromodulation, and after, 70% reported optimism and 62% excitement.
“It’s part of a future where we can use less drugs pumping through our system, causing more side effects, and ending up taking more meds to counteract those. We need to get out of this loop,” said a participant diagnosed with a mental health disorder.
The researchers highlighted the potential for non-invasive neuromodulation to address the challenges of medication adherence, particularly in conditions like major depressive disorder, where 50% of patients do not adhere to their prescribed medication.
“Our study provides valuable insights into the priorities and preferences of current and potential future treatments, finding a preference for non-invasive neuromodulation,” Dr. Kaiser added. “There is a clear opening for government and industry stakeholders to prioritize the development and endorsement of safe, non-invasive brain stimulation treatments.”
The study, titled “Neuromodulation perception by the general public,” was authored by Cyril Atkinson-Clement et al. and published in Scientific Reports (2025). DOI: 10.1038/s41598-025-89437-8.
Disclaimer: This article is based on a survey examining public perception of neuromodulation. While the findings indicate a strong preference for non-invasive interventions, it is important to note that this is a survey, and further clinical research and trials are necessary to validate the effectiveness and safety of these treatments. The information provided in this article should not be interpreted as medical advice. Always consult with a qualified healthcare professional for diagnosis and treatment of any1 medical condition.
