0
0
A new study suggests that amlodipine, a commonly prescribed blood pressure medication, may offer a safer alternative for managing attention-deficit/hyperactivity disorder (ADHD) symptoms. The international study, involving researchers from the University of Surrey, was published in Neuropsychopharmacology and highlights the potential for repurposing this drug for ADHD treatment.
Research Findings
The study tested five potential drugs on rats bred to exhibit ADHD-like symptoms. Among them, only amlodipine significantly reduced hyperactivity. To further validate these findings, the researchers turned to zebrafish, an important model for studying brain function due to their genetic similarity to humans, sharing approximately 70% of human genes.
In zebrafish, amlodipine was found to reduce hyperactivity and impulsivity—two core symptoms of ADHD. Additionally, the study revealed that amlodipine crosses the blood-brain barrier, meaning it can directly affect brain function.
Genetic Link and Human Data
The research team further analyzed human genetic data and found that ADHD is associated with calcium channels in the brain—the same targets affected by amlodipine. This discovery suggests a new potential pathway for ADHD treatment. Additionally, an analysis of patient data from the UK indicated that individuals taking amlodipine reported fewer mood swings and lower levels of risk-taking behavior, supporting its possible efficacy for managing ADHD symptoms.
Expert Insights
Dr. Matthew Parker, co-author of the study from the University of Surrey, emphasized the potential benefits of repurposing amlodipine. “Repurposing amlodipine, a well-established blood pressure medication, offers a promising and swift pathway to address ADHD symptoms. Due to its existing approval and safety profile, amlodipine could be rapidly redeployed as a treatment option for ADHD, potentially providing relief to patients sooner than developing new medications.”
Need for New Treatment Options
Current ADHD medications, while effective, often come with side effects such as appetite loss, high blood pressure, headaches, and sleep disturbances. They also carry a risk of misuse. Amlodipine, being a well-tolerated and widely used medication, could provide a safer alternative. The study highlights the urgency of finding new treatments, as around 25% of ADHD patients do not respond well to existing medications.
Future Directions
While these findings are promising, further clinical trials are necessary to confirm amlodipine’s effectiveness and safety for ADHD patients. Researchers aim to explore its long-term impact and potential integration into ADHD treatment protocols.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Patients should consult their healthcare providers before making any changes to their treatment plans.
