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Pittsburgh, PA – A team of researchers at Carnegie Mellon University has made significant strides in understanding the complex hemodynamics of the human placenta. By developing a computational model of the placentone, the basic functional unit of the placenta, they have laid the groundwork for creating “digital twins” of this vital organ.
Preeclampsia, intrauterine growth restriction, and other pregnancy complications often stem from placental dysfunction. However, studying the placenta in pregnant women presents significant challenges due to ethical and safety concerns.
This research, published in the journal Physics of Fluids, focuses on computationally replicating realistic blood flow within the placenta. By defining key anatomical parameters such as vein location, diameter, and cavity dimensions, the researchers have established a framework for physiologically accurate simulations of a healthy pregnancy.
“Our computational model provides a crucial foundation for understanding how the placenta’s structure influences blood flow,” said Noelia Grande Gutiérrez, Associate Professor of Mechanical Engineering at Carnegie Mellon. “This knowledge is essential for predicting and preventing pregnancy complications.”
The team’s next step involves investigating the impact of abnormal blood flow on placental development, particularly focusing on the effects of incomplete spiral artery remodeling, a condition associated with certain pregnancy complications.
“This research has the potential to revolutionize our understanding of placental function and pave the way for personalized medicine during pregnancy,” said Grande Gutiérrez. “By creating digital twins of the placenta, we can gain valuable insights into the underlying causes of pregnancy disorders and develop more effective treatment strategies.”
Disclaimer: This news article is based on the provided information and may not include all aspects of the research.
Contact: Carnegie Mellon University
