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The World Health Organization (WHO) has approved Bavarian Nordic’s Jynneos vaccine for adolescents aged 12 to 17, marking a significant step in global efforts to curb the spread of mpox (formerly known as monkeypox). This decision, announced on October 8, provides a crucial layer of protection for this vulnerable age group, especially as the virus continues to pose public health challenges.

The approval follows the WHO’s declaration of mpox as a public health emergency, after outbreaks in the Democratic Republic of Congo (DRC) spread to neighboring regions. The decision to prequalify the Jynneos vaccine underscores the urgency of controlling mpox, which has seen a resurgence in recent years. The WHO’s prequalification means the vaccine meets its standards for safety, quality, and efficacy, and it can now be used globally to protect young people in areas at risk.

Global Vaccine Approvals

While the WHO’s recent approval is a key milestone, it follows earlier endorsements from other international health authorities. The European Union (EU) had previously approved the Jynneos vaccine for adolescents, and the U.S. Food and Drug Administration (FDA) authorized its use for teens during the 2022 mpox outbreak. The rapid approval across multiple regions highlights the global recognition of mpox as a serious threat to public health.

In addition to Jynneos, Japan has also rolled out the LC16 vaccine for children, with specific guidelines for its administration. This broadening of vaccine access is critical, particularly for younger populations that are at increased risk of severe outcomes from mpox infections.

A Targeted Response to the Public Health Emergency

Mpox, a viral disease initially endemic to parts of Central and West Africa, has seen a concerning rise in cases outside its traditional geographic range. The recent outbreaks, including cases reported in Europe and North America, have brought new urgency to vaccination efforts, particularly among adolescents who may not have strong immune defenses against the virus.

The WHO’s decision to prioritize this age group reflects growing concerns about the impact of mpox on teens. As the virus can lead to serious complications, particularly in immunocompromised individuals, expanding vaccine availability for adolescents is seen as an essential step in controlling the spread of the virus and protecting high-risk communities.

Next Steps in Global Vaccination Efforts

With WHO’s prequalification of the Jynneos vaccine, countries can now incorporate it into their mpox prevention strategies, targeting both adolescents and other vulnerable populations. Public health officials worldwide are expected to intensify vaccination campaigns, particularly in regions where mpox outbreaks have been recorded.

As global health authorities continue to monitor the situation, the WHO’s approval of Jynneos for teens will likely play a crucial role in mitigating the spread of mpox and preventing future outbreaks. The ongoing focus on vaccine availability and public awareness will be key to protecting populations most at risk and ensuring the global response remains swift and effective.

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