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An investigation suggests that abnormally elevated levels of HDL-cholesterol, often recognized as ‘good cholesterol,’ could potentially raise the risk of dementia among older individuals, as indicated by a study’s findings.
Experts from Monash University in Australia clarified that these exceptionally high HDL-C levels were unusual and not associated with diet but more likely to signify a metabolic disorder. Monira Hussain, a research student at Monash’s School of Public Health and Preventive Medicine, emphasized the importance of further research into the role of very high HDL cholesterol concerning brain health, noting its significance in cardiovascular well-being.
The study, featured in The Lancet Regional Health – Western Pacific, proposes that considering very high HDL cholesterol levels in dementia risk prediction algorithms could be beneficial. The research indicates the potential for identifying older patients, especially those aged 75 and above, who might be at risk of developing dementia.
Over an average duration of 6.3 years, participants with markedly high HDL-C (above 80 mg/dL or below 2.07 mmol/L) exhibited a 27 percent higher risk of dementia compared to those with optimal HDL-C levels. Furthermore, individuals aged 75 years and older with very high levels demonstrated a 42 percent increased risk compared to those maintaining optimal levels.
Very high HDL-C levels were defined as 80 mg/dL (above 2.07 mmol/L) or higher. Generally, maintaining an optimal HDL-C level between 40 to 60 mg/dL (1.03-1.55 mmol/L) for men and 50 to 60 mg/dL (1.55-2.07 mmol/L) for women was seen as beneficial for heart health.
The analysis encompassed 18,668 participants, among whom 2,709 displayed very high HDL-C at the study’s outset. The study noted 38 incidents of dementia among those below 75 years old with very high levels and 101 incidents among those aged 75 and older with elevated HDL-C levels.
